https://www.youngju.dev/blog 천천히 올바르게. AI Researcher & DevOps Engineer Youngju's tech blog. GPU/CUDA, LLM, MLOps, Kubernetes AI workloads, distributed training, and data engineering. ko fjvbn2003@gmail.com (Youngju Kim) fjvbn2003@gmail.com (Youngju Kim) Sat, 16 May 2026 00:00:00 GMT https://www.youngju.dev/blog/culture/2026-05-16-ai-biology-drug-discovery-2026-alphafold-3-rosettafold-esm-atlas-boltz-chai-rfdiffusion-isomorphic-recursion-deep-dive.en https://www.youngju.dev/blog/culture/2026-05-16-ai-biology-drug-discovery-2026-alphafold-3-rosettafold-esm-atlas-boltz-chai-rfdiffusion-isomorphic-recursion-deep-dive.en After the 2024 Nobel Prize in Chemistry went to protein design and AlphaFold, AI biology moved from academia to industry. From the technical differences between AlphaFold 3, RoseTTAFold All-Atom, ESM-3, Boltz-2, Chai-1, RFdiffusion, and ProteinMPNN, to the business models of Isomorphic Labs, Recursion, and Insilico Medicine, plus datasets like PDB, UniProt, ChEMBL and simulation infrastructure like GROMACS and DESMOND — and the AI bio ecosystems of Korea and Japan — this guide maps the hottest AI field of 2026 end to end. Sat, 16 May 2026 00:00:00 GMT fjvbn2003@gmail.com (Youngju Kim) ai-biologydrug-discoveryalphafoldrosettafoldesmboltzchairfdiffusionisomorphic-labsrecursioninsilico-medicineenglish https://www.youngju.dev/blog/culture/2026-05-16-ai-biology-drug-discovery-2026-alphafold-3-rosettafold-esm-atlas-boltz-chai-rfdiffusion-isomorphic-recursion-deep-dive.ja https://www.youngju.dev/blog/culture/2026-05-16-ai-biology-drug-discovery-2026-alphafold-3-rosettafold-esm-atlas-boltz-chai-rfdiffusion-isomorphic-recursion-deep-dive.ja 2024年のノーベル化学賞がタンパク質設計と AlphaFold に贈られて以降、AI 生物学は学術から産業へと移った。AlphaFold 3・RoseTTAFold All-Atom・ESM-3・Boltz-2・Chai-1・RFdiffusion・ProteinMPNN の技術的な違いから、Isomorphic Labs・Recursion・Insilico Medicine のビジネスモデル、PDB・UniProt・ChEMBL などのデータセットや GROMACS・DESMOND といったシミュレーション基盤、そして韓国・日本の AI バイオエコシステムまで — 2026 年現在もっとも熱い AI 分野を一気通貫で整理する。 Sat, 16 May 2026 00:00:00 GMT fjvbn2003@gmail.com (Youngju Kim) ai-biologydrug-discoveryalphafoldrosettafoldesmboltzchairfdiffusionisomorphic-labsrecursioninsilico-medicine日本語 https://www.youngju.dev/blog/culture/2026-05-16-ai-biology-drug-discovery-2026-alphafold-3-rosettafold-esm-atlas-boltz-chai-rfdiffusion-isomorphic-recursion-deep-dive https://www.youngju.dev/blog/culture/2026-05-16-ai-biology-drug-discovery-2026-alphafold-3-rosettafold-esm-atlas-boltz-chai-rfdiffusion-isomorphic-recursion-deep-dive 2024년 노벨 화학상이 단백질 설계와 AlphaFold에 돌아간 이후, AI 생물학은 학문에서 산업으로 이동했다. AlphaFold 3 · RoseTTAFold All-Atom · ESM-3 · Boltz-2 · Chai-1 · RFdiffusion · ProteinMPNN의 기술적 차이부터 Isomorphic Labs · Recursion · Insilico Medicine의 비즈니스 모델, PDB · UniProt · ChEMBL 같은 데이터셋과 GROMACS · DESMOND 같은 시뮬레이션 인프라, 그리고 한국·일본의 AI 바이오 생태계까지 — 2026년 현재 가장 뜨거운 AI 분야를 한 번에 정리한다. Sat, 16 May 2026 00:00:00 GMT fjvbn2003@gmail.com (Youngju Kim) ai-biologydrug-discoveryalphafoldrosettafoldesmboltzchairfdiffusionisomorphic-labsrecursioninsilico-medicine https://www.youngju.dev/blog/culture/2026-05-16-bioinformatics-tools-2026-galaxy-biopython-nextflow-snakemake-alphafold-3-esm3-rosettafold-boltz-1-chai-1-foldseek-deep-dive.en https://www.youngju.dev/blog/culture/2026-05-16-bioinformatics-tools-2026-galaxy-biopython-nextflow-snakemake-alphafold-3-esm3-rosettafold-boltz-1-chai-1-foldseek-deep-dive.en Bioinformatics in 2026 is no longer "install BLAST on Linux and run a Perl script." Galaxy is the standard web UI, Nextflow has unified workflow languages, AlphaFold 3, ESM3, RoseTTAFold, Boltz-1, and Chai-1 made protein structure prediction routine, and the 2024 Nobel Prize in Chemistry went to Baker, Hassabis, and Jumper. This post threads the whole 2026 stack together — data (BCL→FASTQ→BAM→VCF), workflows (Nextflow, Snakemake), alignment and quantification (STAR, Salmon, DESeq2), proteins (AlphaFold 3, ESM3, RoseTTAFold, ProteinMPNN, Boltz-1, Chai-1, Foldseek), single cell (Seurat, Scanpy), and cloud (AWS HealthOmics, GCP Healthcare, Microsoft Genomics). Sat, 16 May 2026 00:00:00 GMT fjvbn2003@gmail.com (Youngju Kim) bioinformaticsgalaxybiopythonbioconductornextflowsnakemakeblastdiamond2mmseqs2samtoolsbcftoolsgatkstarhisat2salmonkallistodeseq2edgerseqeraalphafold-3esm3rosettafoldproteinmpnnbaker-labboltz-1chai-1foldseekanvioqiime-2seuratscanpy10x-genomicsnanoporeaws-healthomics2026deep-diveenglish https://www.youngju.dev/blog/culture/2026-05-16-bioinformatics-tools-2026-galaxy-biopython-nextflow-snakemake-alphafold-3-esm3-rosettafold-boltz-1-chai-1-foldseek-deep-dive.ja https://www.youngju.dev/blog/culture/2026-05-16-bioinformatics-tools-2026-galaxy-biopython-nextflow-snakemake-alphafold-3-esm3-rosettafold-boltz-1-chai-1-foldseek-deep-dive.ja 2026年のバイオインフォマティクスはもはや「Linux に BLAST を入れて Perl スクリプトを回す」学問ではない。Galaxy が Web UI の標準になり、Nextflow がワークフロー言語を統一し、AlphaFold 3・ESM3・RoseTTAFold・Boltz-1・Chai-1 がタンパク質構造予測を日常にし、2024 年のノーベル化学賞は Baker・Hassabis・Jumper に贈られた。本稿はデータ(BCL→FASTQ→BAM→VCF)、ワークフロー(Nextflow・Snakemake)、アラインメント・定量(STAR・Salmon・DESeq2)、タンパク質(AlphaFold 3・ESM3・RoseTTAFold・ProteinMPNN・Boltz-1・Chai-1・Foldseek)、シングルセル(Seurat・Scanpy)、クラウド(AWS HealthOmics・GCP Healthcare・Microsoft Genomics)まで、2026 年のバイオインフォ・スタックを一気に通読する。 Sat, 16 May 2026 00:00:00 GMT fjvbn2003@gmail.com (Youngju Kim) bioinformaticsgalaxybiopythonbioconductornextflowsnakemakeblastdiamond2mmseqs2samtoolsbcftoolsgatkstarhisat2salmonkallistodeseq2edgerseqeraalphafold-3esm3rosettafoldproteinmpnnbaker-labboltz-1chai-1foldseekanvioqiime-2seuratscanpy10x-genomicsnanoporeaws-healthomics2026deep-dive日本語 https://www.youngju.dev/blog/culture/2026-05-16-bioinformatics-tools-2026-galaxy-biopython-nextflow-snakemake-alphafold-3-esm3-rosettafold-boltz-1-chai-1-foldseek-deep-dive https://www.youngju.dev/blog/culture/2026-05-16-bioinformatics-tools-2026-galaxy-biopython-nextflow-snakemake-alphafold-3-esm3-rosettafold-boltz-1-chai-1-foldseek-deep-dive 2026년의 바이오인포매틱스는 더 이상 "리눅스에 BLAST 깔고 펄 스크립트 돌리는" 학문이 아니다. Galaxy가 웹 UI 표준이 되었고, Nextflow가 워크플로 언어를 통일했고, AlphaFold 3·ESM3·RoseTTAFold·Boltz-1·Chai-1이 단백질 구조 예측을 일상으로 만들었고, 2024년 노벨 화학상이 Baker·Hassabis·Jumper에게 돌아갔다. 이 글은 데이터(BCL→FASTQ→BAM→VCF), 워크플로(Nextflow·Snakemake), 정렬·정량(STAR·Salmon·DESeq2), 단백질(AlphaFold 3·ESM3·RoseTTAFold·ProteinMPNN·Boltz-1·Chai-1·Foldseek), 단일세포(Seurat·Scanpy), 클라우드(AWS HealthOmics·GCP Healthcare·Microsoft Genomics)까지 2026년의 바이오인포매틱스 스택을 한 호흡으로 묶는다. Sat, 16 May 2026 00:00:00 GMT fjvbn2003@gmail.com (Youngju Kim) bioinformaticsgalaxybiopythonbioconductornextflowsnakemakeblastdiamond2mmseqs2samtoolsbcftoolsgatkstarhisat2salmonkallistodeseq2edgerseqeraalphafold-3esm3rosettafoldproteinmpnnbaker-labboltz-1chai-1foldseekanvioqiime-2seuratscanpy10x-genomicsnanoporeaws-healthomics2026deep-dive