https://www.youngju.dev/blog 천천히 올바르게. AI Researcher & DevOps Engineer Youngju's tech blog. GPU/CUDA, LLM, MLOps, Kubernetes AI workloads, distributed training, and data engineering. ko fjvbn2003@gmail.com (Youngju Kim) fjvbn2003@gmail.com (Youngju Kim) Sat, 16 May 2026 00:00:00 GMT https://www.youngju.dev/blog/culture/2026-05-16-ai-biology-drug-discovery-2026-alphafold-3-rosettafold-esm-atlas-boltz-chai-rfdiffusion-isomorphic-recursion-deep-dive.en https://www.youngju.dev/blog/culture/2026-05-16-ai-biology-drug-discovery-2026-alphafold-3-rosettafold-esm-atlas-boltz-chai-rfdiffusion-isomorphic-recursion-deep-dive.en After the 2024 Nobel Prize in Chemistry went to protein design and AlphaFold, AI biology moved from academia to industry. From the technical differences between AlphaFold 3, RoseTTAFold All-Atom, ESM-3, Boltz-2, Chai-1, RFdiffusion, and ProteinMPNN, to the business models of Isomorphic Labs, Recursion, and Insilico Medicine, plus datasets like PDB, UniProt, ChEMBL and simulation infrastructure like GROMACS and DESMOND — and the AI bio ecosystems of Korea and Japan — this guide maps the hottest AI field of 2026 end to end. Sat, 16 May 2026 00:00:00 GMT fjvbn2003@gmail.com (Youngju Kim) ai-biologydrug-discoveryalphafoldrosettafoldesmboltzchairfdiffusionisomorphic-labsrecursioninsilico-medicineenglish https://www.youngju.dev/blog/culture/2026-05-16-ai-biology-drug-discovery-2026-alphafold-3-rosettafold-esm-atlas-boltz-chai-rfdiffusion-isomorphic-recursion-deep-dive.ja https://www.youngju.dev/blog/culture/2026-05-16-ai-biology-drug-discovery-2026-alphafold-3-rosettafold-esm-atlas-boltz-chai-rfdiffusion-isomorphic-recursion-deep-dive.ja 2024年のノーベル化学賞がタンパク質設計と AlphaFold に贈られて以降、AI 生物学は学術から産業へと移った。AlphaFold 3・RoseTTAFold All-Atom・ESM-3・Boltz-2・Chai-1・RFdiffusion・ProteinMPNN の技術的な違いから、Isomorphic Labs・Recursion・Insilico Medicine のビジネスモデル、PDB・UniProt・ChEMBL などのデータセットや GROMACS・DESMOND といったシミュレーション基盤、そして韓国・日本の AI バイオエコシステムまで — 2026 年現在もっとも熱い AI 分野を一気通貫で整理する。 Sat, 16 May 2026 00:00:00 GMT fjvbn2003@gmail.com (Youngju Kim) ai-biologydrug-discoveryalphafoldrosettafoldesmboltzchairfdiffusionisomorphic-labsrecursioninsilico-medicine日本語 https://www.youngju.dev/blog/culture/2026-05-16-ai-biology-drug-discovery-2026-alphafold-3-rosettafold-esm-atlas-boltz-chai-rfdiffusion-isomorphic-recursion-deep-dive https://www.youngju.dev/blog/culture/2026-05-16-ai-biology-drug-discovery-2026-alphafold-3-rosettafold-esm-atlas-boltz-chai-rfdiffusion-isomorphic-recursion-deep-dive 2024년 노벨 화학상이 단백질 설계와 AlphaFold에 돌아간 이후, AI 생물학은 학문에서 산업으로 이동했다. AlphaFold 3 · RoseTTAFold All-Atom · ESM-3 · Boltz-2 · Chai-1 · RFdiffusion · ProteinMPNN의 기술적 차이부터 Isomorphic Labs · Recursion · Insilico Medicine의 비즈니스 모델, PDB · UniProt · ChEMBL 같은 데이터셋과 GROMACS · DESMOND 같은 시뮬레이션 인프라, 그리고 한국·일본의 AI 바이오 생태계까지 — 2026년 현재 가장 뜨거운 AI 분야를 한 번에 정리한다. Sat, 16 May 2026 00:00:00 GMT fjvbn2003@gmail.com (Youngju Kim) ai-biologydrug-discoveryalphafoldrosettafoldesmboltzchairfdiffusionisomorphic-labsrecursioninsilico-medicine https://www.youngju.dev/blog/culture/2026-05-16-ai-character-chat-companion-2026-character-ai-replika-chai-janitor-talkie-polybuzz-crushon-pi-ai-deep-dive.en https://www.youngju.dev/blog/culture/2026-05-16-ai-character-chat-companion-2026-character-ai-replika-chai-janitor-talkie-polybuzz-crushon-pi-ai-deep-dive.en In May 2026 the AI character chat and companion AI space has hardened into a sprawling shadow industry. Character.AI still hovers around 20M monthly users even after sending Noam Shazeer back to Google, while the October 2024 Florida teen suicide lawsuit becomes the first civil-liability bellwether. Replika partially reversed its February 2023 ERP block after community trauma, and Pi by Inflection became a B2B AI shop after Mustafa Suleyman left for Microsoft. Janitor AI, SpicyChat, and Crushon allow NSFW openly and run a proxy economy, while SillyTavern is the de facto self-host frontend. Korea has Wrtn Character and Scatter Lab Iruda, Japan has its own kyara-chat ecosystem. With the UK Online Safety Act and Florida SB 1308 closing in, this post walks 50+ services end to end. Sat, 16 May 2026 00:00:00 GMT fjvbn2003@gmail.com (Youngju Kim) ai-character-chatcompanion-aicharacter-aireplikachaijanitortalkiepolybuzzcrushonpi-aiai-dungeonenglish https://www.youngju.dev/blog/culture/2026-05-16-ai-character-chat-companion-2026-character-ai-replika-chai-janitor-talkie-polybuzz-crushon-pi-ai-deep-dive.ja https://www.youngju.dev/blog/culture/2026-05-16-ai-character-chat-companion-2026-character-ai-replika-chai-janitor-talkie-polybuzz-crushon-pi-ai-deep-dive.ja 2026年5月時点で、AIキャラクターチャットとコンパニオンAIは巨大な影の産業として定着した。Character.AIはNoam ShazeerをGoogleへ戻したあとも月間2,000万人規模を維持しているが、2024年10月のフロリダ10代自殺訴訟が初の民事責任の試金石になりつつある。Replikaは2023年2月のERP遮断騒動を経て一部復活し、PiはMustafa SuleymanがMicrosoftに移ったあとB2BのAI会社へ転身した。Janitor AI、SpicyChat、CrushonはNSFWを明示的に許容しプロキシ経済を運営、SillyTavernは事実上のセルフホスト・フロントエンドになった。韓国にはWrtn CharacterとScatter Labのイルダ、日本には独自のキャラチャット生態系がある。UK Online Safety Actとフロリダ州SB 1308が迫る中、50以上のサービスを一気通貫で整理する。 Sat, 16 May 2026 00:00:00 GMT fjvbn2003@gmail.com (Youngju Kim) ai-character-chatcompanion-aicharacter-aireplikachaijanitortalkiepolybuzzcrushonpi-aiai-dungeon日本語 https://www.youngju.dev/blog/culture/2026-05-16-ai-character-chat-companion-2026-character-ai-replika-chai-janitor-talkie-polybuzz-crushon-pi-ai-deep-dive https://www.youngju.dev/blog/culture/2026-05-16-ai-character-chat-companion-2026-character-ai-replika-chai-janitor-talkie-polybuzz-crushon-pi-ai-deep-dive 2026년 5월 현재 AI 캐릭터 챗과 컴패니언 AI 시장은 거대한 그림자 산업으로 굳어졌다. Character.AI는 Noam Shazeer를 Google에 돌려보낸 뒤에도 월 2천만 명대 사용자를 유지하지만, 2024년 10월 플로리다 10대 자살 소송이 첫 형사·민사 책임 판례로 가는 중이다. Replika는 2023년 2월 ERP 차단으로 사용자 트라우마를 만든 뒤 부분 복원했고, Pi by Inflection은 Mustafa Suleyman이 Microsoft로 가면서 B2B AI 회사로 변신했다. Janitor AI, SpicyChat, Crushon은 NSFW를 허용하면서 프록시·자체 모델 전쟁을 벌이고, SillyTavern은 자체 호스팅 프론트엔드의 표준이 됐다. 한국은 뤼튼 캐릭터와 Scatter Lab 이루다, 일본은 키ャラ챗 생태계가 따로 존재한다. UK Online Safety Act와 미국 SB 1308이 다가오는 가운데 50여 개 서비스를 한 호흡에 정리한다. Sat, 16 May 2026 00:00:00 GMT fjvbn2003@gmail.com (Youngju Kim) ai-character-chatcompanion-aicharacter-aireplikachaijanitortalkiepolybuzzcrushonpi-aiai-dungeon